https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:49862 Wed 28 Feb 2024 15:09:16 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:24092 Wed 24 Nov 2021 15:51:30 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36970 Wed 24 May 2023 13:04:36 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36968 2 [IQR 7–21]) compared to benign thyroid (6 nerves/cm² [IQR: 3–10]) (p = 0.001). In contrast, no increase in nerve density was observed in FTC. In multivariate analysis, nerve density correlated positively with extrathyroidal invasion (p < 0.001), and inversely with tumour size (p < 0.001). The majority of nerves were adrenergic, although cholinergic and peptidergic innervation was detected. Perineural invasion was present in 35% of PTC, and was independently associated with extrathyroidal invasion (p = 0.008). This is the first report of infiltration of nerves into the tumour microenvironment of thyroid cancer and its association with tumour aggressiveness. The role of nerves in thyroid cancer pathogenesis should be further investigated.]]> Wed 24 May 2023 12:56:43 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:48936 Wed 19 Apr 2023 14:55:13 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:37075 vs 21.4 (5.1) cm³; P = 0.027) despite no significant difference in body weight. Despite having a smaller TRV, there was no significant difference in eGFR between Indigenous and Non-indigenous neonates (47.8 [43.2-50.4] vs 46.2 [42.6-53.3] ml/min per 1.73 m²; P = 0.986). These infants achieve similar eGFR through hyperfiltration, which likely increases their future risk of CKD. There was no difference in microalbumin-creatinine ratio. Female Indigenous neonates, however, had significantly smaller TRV compared with Indigenous male neonates (15.9 (3.6) vs 20.6 (3.6) cm³; P = 0.006), despite no difference in eGFR, birth weight, gestational age, and weight at term corrected. Conclusion: The difference in TRV is likely to be an important risk factor for the difference in morbidity and mortality from renal disease reported between male and female Indigenous adults.]]> Wed 15 Dec 2021 16:07:38 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:49912 Wed 14 Jun 2023 16:05:47 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:49867 Wed 14 Jun 2023 12:16:34 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52471 Wed 11 Oct 2023 20:44:03 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:26738 Wed 11 Apr 2018 16:54:59 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36989 Wed 10 Nov 2021 15:12:54 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:37441 Wed 09 Mar 2022 15:59:58 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32096 Wed 09 Feb 2022 15:57:52 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:38051 Wed 09 Aug 2023 12:59:50 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:49872 Wed 07 Jun 2023 16:01:37 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:49869 Wed 07 Jun 2023 15:54:43 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:49860  rolipram > glycyl-H-1152 > HC-067047 > 2-APB > indomethacin > aminophylline. These data provide greater insight into the contraction-blocking properties of some novel tocolytics, with glycyl-H-1152, in particular, emerging as a potential novel tocolytic for preventing preterm birth.]]> Wed 07 Jun 2023 12:17:36 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32091 Wed 06 Apr 2022 14:04:13 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:35270 Wed 06 Apr 2022 14:02:10 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43981 Wed 05 Oct 2022 14:29:29 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30359 Wed 04 Sep 2019 09:47:44 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30955 Wed 02 Oct 2019 10:21:46 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:49736 Tue 30 May 2023 13:37:59 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:44767 Tue 30 May 2023 11:48:47 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:33632 Tue 27 Nov 2018 16:39:25 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36640 Tue 25 Oct 2022 09:27:51 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:21812 n = 131) were recruited as part of a longitudinal study while attending antenatal care clinics during pregnancy; blood samples were collected up to three times in pregnancy. Serum cotinine, indicating exposure to cigarette smoke, was detected in 50.4% of mothers. Compared with non-Indigenous women, the cohort had 10 times the prevalence of antibodies to Helicobacter pylori (33 vs. 3%). Levels of immunoglobulin G, antibodies to H. pylori, and C-reactive protein (CRP) were all inversely correlated with gestational age (P < 0.05). CRP levels were positively associated with maternal body mass index (BMI; ρ = 0.449, P = 0.001). The effects of cigarette smoke (cotinine) and inflammation (CRP) were assessed in relation to risk factors for SIDS: gestational age at delivery and birth weight. Serum cotinine levels were negatively associated with birth weight (ρ = -0.37, P < 0.001), this correlation held true for both male (ρ = -0.39, P = 0.002) and female (ρ = -0.30, P = 0.017) infants. Cotinine was negatively associated with gestational age at delivery (ρ = -0.199, P = 0.023). When assessed by fetal sex, this was significant only for males (ρ = -0.327, P = 0.011). CRP was negatively associated with gestational age at delivery for female infants (ρ = -0.46, P < 0.001). In contrast, maternal BMI was significantly correlated with birth weight. These data highlight the importance of putting programs in place to reduce cigarette smoke exposure in pregnancy and to treat women with chronic infections such as H. pylori to improve pregnancy outcomes and decrease risk factors for sudden death in infancy.]]> Tue 24 Apr 2018 16:00:57 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30964 100) epialleles. RNA-polymerase-II (Pol-II) bound only to three particular epialleles in cAMP-stimulated cells, while phospho-cAMP response element-binding protein (pCREB) bound to only one epiallele, which was different from those selected by Pol-II. Binding of TATA-binding protein increased during syncytial differentiation preferentially at epialleles compatible with Pol-II and pCREB binding. Histone-3 acetylation was detected only at epialleles targeted by Pol-II and pCREB, while gene activating histone-4 acetylation and histone-3-lysine-4 trimethylation occurred at CRH epialleles not associated with Pol-II or pCREB. The suppressive histone-3-lysine-27 trimethyl and-lysine-9 trimethyl modifications showed little or no epiallele preference. The epiallele selectivity of activating histone modifications and transcription factor binding demonstrates the epigenetic and functional diversity of the CRH gene in trophoblasts, which is controlled predominantly by the patterns, not the overall extent, of promoter methylation. We propose that conditions impacting on epiallele distribution influence the number of transcriptionally active CRH gene copies in the trophoblast cell population determining the gestational trajectory of placental CRH production in normal and pathological pregnancies.]]> Tue 24 Apr 2018 15:36:22 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:29245 Tue 24 Apr 2018 12:01:37 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:23393 Tue 24 Apr 2018 11:33:54 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36685 in utero and early life insults and the development of chronic illness remains to be fully understood, but there is increasing data to indicate that microvasculature pathology plays an important mechanistic role. Currently available data indicate that retinal microvasculature changes are detectable in children as young as six years of age, however, there are no data for younger children. We present retinal microvasculature measurement from the first two years of life. Retinal images suitable for analysis were available from 18 infants in our proof-of-concept study. The mean and standard deviation (SD)for birth weight and gestation was 3410 (384)g and 39.1(1.4)weeks, respectively. Retinal vessel calibres were summarized as the mean(SD)central retinal arteriolar equivalent (CRAE)at six months of age was 156 (32)µm, increased to 175 (75)µm by 12 months and a slightly declined by 24 months of age to 168 (50)µm. In a similar pattern, mean(SD)central retinal venular equivalent (CRVE)at six months was 211 (19)µm, increased to 238 (25)µm by 12 months of age followed by a slight decline at 24 months of age to 222 (36)µm. The arterio-venous ratio and tortuosity index remained the same at 6, 12 and 24 months. Findings from this study could help future investigators better understand early microvasculature changes and adaptation that occur early in life.]]> Tue 23 Jun 2020 17:02:42 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54380 Tue 20 Feb 2024 20:33:09 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54358 Tue 20 Feb 2024 16:26:17 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54348 Tue 20 Feb 2024 16:20:31 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40856 Tue 19 Jul 2022 13:35:20 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:44624 P<.0001; with adjustment for infant sex and maternal body mass index). Indigenous mean birthweight percentile was 4.2 units lower (P<.0001). Adjustment for maternal age, smoking, body mass index, and infant sex reduced the difference in birthweight/percentiles to nonsignificance (12 g; P=.07). Conclusion: Disparities exist between indigenous and non-indigenous Australian infants for birthweight, birthweight percentile, and adverse outcome rates. Adjustment for smoking and maternal age removed any significant difference in birthweights and birthweight percentiles for indigenous infants. Our data indicate that birthweight percentiles should not be adjusted for indigenous ethnicity because this normalizes disadvantage; because White and indigenous Australians have diverged for approximately 50,000 years, it is likely that the same conclusions apply to other ethnic groups. The disparities in birthweight percentiles that are associated with smoking will likely perpetuate indigenous disadvantage into the future because low birthweight is linked to the development of chronic noncommunicable disease and poorer educational attainment; similar problems may affect other indigenous populations.]]> Tue 18 Oct 2022 11:09:49 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:48295 Tue 14 Mar 2023 13:09:59 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:39116 Tue 10 May 2022 15:01:34 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:39113 Tue 10 May 2022 14:47:41 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36997 Thu 30 Jul 2020 16:38:14 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54561 Thu 29 Feb 2024 12:33:44 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32097 Thu 28 Oct 2021 12:37:05 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:34938 Thu 28 Oct 2021 12:36:30 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45400 Thu 27 Oct 2022 17:36:16 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45377 Thu 27 Oct 2022 16:12:31 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45378 Thu 27 Oct 2022 16:12:15 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32076 Thu 27 Jan 2022 15:57:09 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:33393 Thu 24 Mar 2022 11:30:34 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51190 Thu 24 Aug 2023 14:39:18 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:35858 Thu 21 Oct 2021 12:45:46 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:41024 Thu 21 Jul 2022 12:15:19 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:24422 Thu 20 Sep 2018 14:53:11 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32094 Thu 17 Mar 2022 14:40:51 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:35064 Thu 17 Mar 2022 14:37:02 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32093 Thu 17 Feb 2022 09:30:56 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:55338 Thu 16 May 2024 16:23:05 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40081 Thu 14 Jul 2022 11:54:12 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40524 Thu 14 Jul 2022 09:26:17 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:31115 Thu 14 Apr 2022 11:03:58 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36470 Thu 14 Apr 2022 11:00:48 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:37084 Thu 14 Apr 2022 10:59:52 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:37077 Thu 13 Aug 2020 16:17:43 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45421 Thu 10 Nov 2022 10:30:53 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:34951 Thu 09 Dec 2021 11:04:52 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30931 41 completed weeks of gestation (late-term) would show changes consistent with aging that would also be present in placentas associated with stillbirths. Objective: We sought to determine whether placentas from late-term pregnancies and unexplained stillbirth show oxidative damage and other biochemical signs of aging. We also aimed to develop an in vitro term placental explant culture model to test the aging pathways. Study Design: We collected placentas from women at 37-39 weeks’ gestation (early-term and term), late-term, and with unexplained stillbirth. We used immunohistochemistry to compare the 3 groups for: DNA/RNA oxidation (8-hydroxy-deoxyguanosine), lysosomal distribution (lysosome-associated membrane protein 2), lipid oxidation (4-hydroxynonenal), and autophagosome size (microtubule-associated proteins 1A/1B light chain 3B, LC3B). The expression of aldehyde oxidase 1 was measured by real-time polymerase chain reaction. Using a placental explant culture model, we tested the hypothesis that aldehyde oxidase 1 mediates oxidative damage to lipids in the placenta. Results: Placentas from late-term pregnancies show increased aldehyde oxidase 1 expression, oxidation of DNA/RNA and lipid, perinuclear location of lysosomes, and larger autophagosomes compared to placentas from women delivered at 37-39 weeks. Stillbirth-associated placentas showed similar changes in oxidation of DNA/RNA and lipid, lysosomal location, and autophagosome size to placentas from late-term. Placental explants from term deliveries cultured in serum-free medium also showed evidence of oxidation of lipid, perinuclear lysosomes, and larger autophagosomes, changes that were blocked by the G-protein-coupled estrogen receptor 1 agonist G1, while the oxidation of lipid was blocked by the aldehyde oxidase 1 inhibitor raloxifene. Conclusion: Our data are consistent with a role for aldehyde oxidase 1 and G-protein-coupled estrogen receptor 1 in mediating aging of the placenta that may contribute to stillbirth. The placenta is a tractable model of aging in human tissue.]]> Thu 09 Dec 2021 11:03:44 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:49875 Thu 08 Jun 2023 13:57:36 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36724 Thu 04 Nov 2021 10:39:48 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:35583 th week of gestation. Educational status, previous use of antenatal care and best friend’s use of maternal care were significant predisposing factors associated with at least one antenatal care visit. Type of kebele, wealth index and husband’s attitude towards antenatal care were significant enabling factors associated with at least one antenatal care consultation. Health Extension Workers providing home visits, perceived importance of ANC and awareness of pregnancy complications were significant need factor associated with at least one antenatal care consultation. Husband’s attitude towards ANC, head of the household, awareness of pregnancy complications, and history of abortion were predictors of attending four or more antenatal care visits. Conclusion: More than half of the women attended at least one antenatal care visit. A sizable proportion of women had infrequent and delayed antenatal care. Intervention efforts to improve antenatal care utilization should involve the following: improving women’s educational achievement, peer education programs to mobilize and support women, programs to change husbands’ attitudes, ameliorate the quality of antenatal care, increasing the Health Extension Worker’s home visits program, and increasing the awareness of pregnancy complications.]]> Thu 04 Nov 2021 10:38:40 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:48123 Thu 02 Mar 2023 14:17:32 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36340 Thu 02 Mar 2023 14:17:32 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:42698 Thu 01 Sep 2022 09:34:25 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30848 Sat 24 Mar 2018 07:33:54 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:34950 Mon 27 May 2019 12:39:55 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32092 Mon 23 Sep 2019 12:35:23 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32049 Mon 23 Sep 2019 11:46:34 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32077 0.05). Global DNA methylation levels in males were significantly higher than in females (median %5-mC: 1.82 vs. 1.03, males and females respectively, (P < 0.05)). Conclusion: No association was found between the intake of one-carbon metabolism nutrients during the early postnatal period and global DNA methylation levels at age four years. Higher global DNA methylation levels in males warrants further investigation.]]> Mon 23 Sep 2019 11:18:49 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32099 Mon 23 Sep 2019 11:17:25 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32095 Mon 23 Sep 2019 10:19:30 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47510 Mon 23 Jan 2023 12:08:39 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:39754 Mon 20 Jun 2022 12:01:11 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:49959 Mon 19 Jun 2023 13:06:46 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:49910 Mon 19 Jun 2023 11:07:36 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:49847 Mon 05 Jun 2023 15:51:30 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:49835 Mon 05 Jun 2023 13:52:33 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45462 Fri 28 Oct 2022 14:41:08 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36971 Fri 24 Jul 2020 13:59:42 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54926 Fri 22 Mar 2024 14:33:40 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36972 Fri 21 Oct 2022 14:58:01 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36624 Fri 21 Oct 2022 12:10:07 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50835 Fri 18 Aug 2023 10:27:30 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40579 Fri 15 Jul 2022 10:25:21 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40011 p > .05), though the estimates of effect were consistently negative. Global DNA methylation levels in males were significantly higher than in females (median %5mC: 1.82 vs. 1.03, males and females, respectively, (p < .05)). Conclusion: No association was found between global DNA methylation and child cognition and behavior; however given the small sample, this study should be pooled with other cohorts in future meta-analyses.]]> Fri 15 Jul 2022 10:09:55 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:37092 Fri 14 Aug 2020 15:16:50 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:37083 Fri 14 Aug 2020 14:27:46 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:48165 Fri 10 Mar 2023 17:14:38 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:35582 Fri 06 Sep 2019 13:35:09 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32098 Fri 03 Dec 2021 10:35:09 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:49834 Fri 02 Jun 2023 15:50:44 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46861 Fri 02 Dec 2022 11:05:23 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36967 28 weeks) and kidney function in infants, <2.5 years of age, from the Gomeroi gaaynggal cohort. Pre‐pregnancy body mass index (BMI) was recorded at the first prenatal visit and maternal adiposity indicators (percent body fat and visceral fat area) measured at >28 weeks gestation by bioelectrical impedance analysis. Fetal kidney structure was assessed by ultrasound. Renal function indicators (urinary albumin:creatinine and protein:creatinine) were measured in infants from a spot urine collection from nappies. Multiple linear regression and multi‐level mixed effects linear regression models with clustering were used to account for repeated measures of urine. 147 mother–child pairs were examined. Estimated fetal weight (EFW), but not fetal kidney size, was positively associated with maternal adiposity and pre‐pregnancy BMI. When adjusted for smoking, combined kidney volume relative to EFW was negatively associated with maternal percentage body fat. Infant kidney function was not influenced by maternal adiposity and pre‐pregnancy BMI (n = 84 observations). Current findings show that Indigenous babies born to obese mothers have reduced kidney size relative to EFW. We suggest that these babies are experiencing a degree of glomerular hyperfiltration in utero, and therefore are at risk of developing CKD in later life, especially if their propensity for obesity is maintained. Although no impact on renal function was observed at <2.5 years of age, long‐term follow‐up of offspring is required to evaluate potential later life impacts.]]> Fri 01 Apr 2022 09:27:39 AEDT ]]>